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KMID : 0613820020120020182
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Journal of Life Science
2002 Volume.12 No. 2 p.182 ~ p.187
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Extracts of Caesalpina sappan L. Potentiate the Apoptosis of NIH3T3 Cells Exposed to Methymethane Sulfonate
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Hwang Sung-Jin
Lee Jung-Sub
Jeon Byung-Hoon
Kim Won-Sin
Woo Eun-Rhan
Park Jong-Kun
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Abstract
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In this study we have investigated the effect of Caesalpina sappann L. extracts on the apoptosis in NIH3T3 cells exposed to methylmethan sulfonate (MMS), an alkylating agent. MTT assay study showed that Caesalpina sappan L. extracts potentiate the MMS-induced viability. Cell morphology studies, acridine orange (AO) staining, and DNA fragmentation analysis indicated that the postincubation of Caesalpina sappan L. extracts increase the nuclear condensation of MMS-induced apoptotosis. These results suggest that Caesalpina sappan L. extracts contain components potentiating MMS-induced apoptosis of NIH3T3 cells.
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KEYWORD
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Caesalpina sappan L., MMS, apoptosis, NIH3T3
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